What my genotype indicates about my future

A few days ago, I shared the ancestry part of my DNA results.  Now I'd like to share the very interesting health results I received.

(1)  Disease Risk
         For someone with my genotype compared with average:
     
         I am at a higher risk for:

• Venous Thromboembolism (blood clots)
• Type 2 Diabetes
• Age-related Macular Degenration
• Atrial Fibrillation (irregular heart rhythm)
•  Psoriasis
• Colorectal Cancer
• Exfoliation Glaucoma (I already have glaucoma.) 
• Ulcerative Colitis
• Scleroderma (Limited Cutaneous Type)

        I am at a lower risk for:

•  Breast cancer
• Alzheimer's Disease
• Restless Leg Syndrome
• Rheumatoid Arthritis
• Melanoma
• Parkinson's Disease
• Multiple Sclerosis
• Celiac Disease
• Crohn's Disease
• Type 1 Diabetes
• Esophageal Squamous Cell Carcinoma (ESCC)
• Stomach Cancer (Gastric Cardia Adenocarcinoma)

What really surprised me is that I have only an average risk of having Coronary Heart Disease.

(2)  Carrier Status
         The variant is present for:

• Hemochromatosis (iron overload)

In people with hemochromatosis, iron builds up in the body, causing organ damage— especially in the liver. (23andme.com)

  (3)  Drug Response
         Increased chance of hypersensitivity to:

•  Oral Contraceptives, Hormone Replacement Therapy and Risk of Venous Thromboembolism



Warfarin is a drug that can help prevent blood clots. (23andme.com)

• Warfarin (Coumadin®) Sensitivity
• Heroin Addiction (Really?!  I do not think I need to worry about this one!) 
• Postoperative Nausea and Vomiting (This is interesting... as I have never experienced this before.)

(4)  Traits

•  Lactose Intolerance:  Likely tolerant
• Malaria Resistance:  Not resistant  (There goes my African safari!)
• Norovirus Resistance:  Not resistant

The good news is that I did not have an increased risk of Alzheimer's, Parkinson's Disease, MS, Lou Gehrig's Disease, or most cancers.  I have to admit this does relieve my mind. 

I do know that none of this is carved in stone.  However, it does give me a good idea of what to be vigilant about.  

Tonight, I sent out invitations to five of those in Relative Finder who showed the highest percentages of matching my DNA profile.  I did not have anyone closer than a 4th cousin show up, but the way I'm collecting cousins lately (A story for another blog post!), what's a few more?